An integrated bioinformatic investigation of succinic acid metabolism related genes in ccRCC followed by preliminary validation of SLC25A4 in tumorigenesis

Abstract The defective function of succinate dehydrogenase promotes the development and progression of kidney renal clear cell renal cell carcinoma (ccRCC). However, the molecular mechanism of succinate metabolism-related genes (SMRGs) has not been extensively studied in KIRC. First, differentially...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Dong Yue, Fengyun Dong, Sen Wang, Miao Zheng
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-06-01
Subjects:	Clear cell renal cell carcinoma Succinate metabolism-related genes Risk score Prognosis
Online Access:	https://doi.org/10.1038/s41598-025-03102-8