Stability Analysis of the Asiatic Acid-COX-2 Complex Using 100 ns Molecular Dynamic Simulations and Its Selectivity against COX-2 as a Potential Anti-Inflammatory Candidate

Asiatic acid, a triterpenoid compound, has been shown to have anti-inflammatory activity through the inhibition of the formation of cyclooxygenase-2 (COX-2) in vitro and in vivo. This study was conducted to determine the binding stability and the inhibitory potential of asiatic acid as an anti-infla...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Ida Musfiroh, Rahmana E. Kartasasmita, Slamet Ibrahim, Muchtaridi Muchtaridi, Syahrul Hidayat, Nur Kusaira Khairul Ikram
Format:	Article
Language:	English
Published:	MDPI AG 2023-04-01
Subjects:	asiatic acid COX-2 IC<sub>50</sub> molecular dynamic simulation anti-inflammatory
Online Access:	https://www.mdpi.com/1420-3049/28/9/3762