A JAK of all trades: how global phosphoproteomics reveal the Achilles heel of MPNs

While Janus-kinase (JAK)-inhibitors effectively reduce the inflammatory phenotype of myeloproliferative neoplasms (MPN), they do not affect disease burden or presence of the mutated clone to a major extent. Here, we show how Janus-kinase 2 (JAK2)-mutated cells persist through maintenance of the mito...

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Bibliographic Details

Published in:	Molecular & Cellular Oncology
Main Authors:	Tina M. Schnoeder, Florian Perner, Florian H. Heidel
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2021-03-01
Subjects:	jak2 mpn clonal persistence
Online Access:	http://dx.doi.org/10.1080/23723556.2020.1871172