Decursin induces FLT3-ITD acute myeloid leukemia cell apoptosis by increasing the expression of the ubiquitin-conjugase UBE2L6

Abstract Mutation in the internal tandem duplication sequence of the FLT3 gene (FLT3-ITD) is linked to a poor clinical prognosis in acute myeloid leukemia (AML) patients. FLT3 inhibitors have demonstrated efficacy in improving the prognosis of AML patients with FLT3-ITD. However, the efficacy of FLT...

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Bibliographic Details
Published in:Cell Communication and Signaling
Main Authors: Tianxin Zhang, Yuchen Li, Wenhao Liao, Yu Mou, Xue Zhan, Qiongying Hu, Ziyi Zhao, Daqian Xiong
Format: Article
Language:English
Published: BMC 2025-04-01
Subjects:
AML
Decursin
Degradation
FLT3-ITD
UBE2L6
Online Access:https://doi.org/10.1186/s12964-025-02157-4

Internet

https://doi.org/10.1186/s12964-025-02157-4

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