Heparin-enriched plasma proteome is significantly altered in Alzheimer’s disease

Abstract Introduction Heparin binding proteins (HBPs) with roles in extracellular matrix assembly are strongly correlated to β-amyloid (Aβ) and tau pathology in Alzheimer’s disease (AD) brain and cerebrospinal fluid (CSF). However, it remains challenging to detect these proteins in plasma using stan...

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Bibliographic Details

Published in:	Molecular Neurodegeneration
Main Authors:	Qi Guo, Lingyan Ping, Eric B. Dammer, Duc M. Duong, Luming Yin, Kaiming Xu, Anantharaman Shantaraman, Edward J. Fox, Todd E Golde, Erik C.B. Johnson, Blaine R. Roberts, James J. Lah, Allan I. Levey, Nicholas T. Seyfried
Format:	Article
Language:	English
Published:	BMC 2024-10-01
Subjects:	Alzheimer’s disease Amyloid Biomarkers Cerebrospinal fluid Heparin Heparan sulfate proteoglycans
Online Access:	https://doi.org/10.1186/s13024-024-00757-1