Rod photoreceptor-specific deletion of cytosolic aspartate aminotransferase, GOT1, causes retinal degeneration

Photoreceptor cell death is the cause of vision loss in many forms of retinal disease. Metabolic dysfunction within the outer retina has been shown to be an underlying factor contributing to photoreceptor loss. Therefore, a comprehensive understanding of the metabolic pathways essential to photorece...

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Bibliographic Details

Published in:	Frontiers in Ophthalmology
Main Authors:	Shubha Subramanya, Moloy T. Goswami, Nicholas Miller, Eric Weh, Sraboni Chaudhury, Li Zhang, Anthony Andren, Heather Hager, Katherine M. Weh, Costas A. Lyssiotis, Cagri G. Besirli, Thomas J. Wubben
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-12-01
Subjects:	photoreceptor GOT1 malate-aspartate shuttle redox TCA cycle metabolism
Online Access:	https://www.frontiersin.org/articles/10.3389/fopht.2023.1306019/full