Drug-induced hepatotoxicity and association with slow acetylation variants NAT2*5 and NAT2*6 in Cameroonian patients with tuberculosis and HIV co-infection

Abstract Background Human immunodeficiency virus (HIV) and tuberculosis (TB) are major contributors to morbidity and mortality in sub-Saharan Africa including Cameroon. Pharmacogenetic variants could serve as predictors of drug-induced hepatotoxicity (DIH), in patients with TB co-infected with HIV....

Full description

Bibliographic Details

Published in:	BMC Infectious Diseases
Main Authors:	Frederick Nchang Cho, Eric A. Achidi, Jude Eteneneng Enoh, Srinivas Reddy Pallerla, Le Thi Kieu Linh, Hoang Van Tong, Joseph Kamgno, Véronique Beng Penlap, Ayola Akim Adegnika, Jean-Bernard Lekana-Douki, Marielle Karine Bouyou-Akotet, Gauthier Mesia Kahunu, Gaston Tona Lutete, Mathew Bates, John Tembo, Linzy Elton, Timothy D McHugh, Martin P Grobusch, Alimuddin Zumla, Francine Ntoumi, Thirumalaisamy P. Velavan
Format:	Article
Language:	English
Published:	BMC 2024-07-01
Subjects:	Pharmacogenetics Drug-induced hepatotoxicity Co-infection HIV Tuberculosis
Online Access:	https://doi.org/10.1186/s12879-024-09638-w