Methylglyoxal, a Reactive Glucose Metabolite, Induces Bladder Overactivity in Addition to Inflammation in Mice

Diabetic bladder dysfunction (DBD) is one of the most common complication of diabetes. Methylglyoxal (MGO), a highly reactive dicarbonyl compound formed as a by-product of glycolysis, is found at high levels in plasma of diabetic patients. Here, we explored the effects of chronic administration of M...

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Bibliographic Details

Published in:	Frontiers in Physiology
Main Authors:	Mariana G. de Oliveira, Matheus L. de Medeiros, Edith B. G. Tavares, Fabiola Z. Mónica, Edson Antunes
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-04-01
Subjects:	advanced glycation end products cystometry transient receptor potential muscarinic receptors NF-kB inducible nitric oxide synthase
Online Access:	https://www.frontiersin.org/article/10.3389/fphys.2020.00290/full