Identification and validation of diagnostic biomarkers for intrahepatic cholestasis of pregnancy based on untargeted and targeted metabolomics analyses of urine metabolite profiles

Abstract Background Intrahepatic cholestasis of pregnancy (ICP) is a prevalent pregnancy-specific complication that presents with maternal itching and elevated serum bile acid levels. ICP is associated with unfavorable pregnancy outcomes, severely decreasing the pregnant woman’s quality of life. Tim...

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Bibliographic Details

Published in:	BMC Pregnancy and Childbirth
Main Authors:	Weici Liu, Lingyan Chen, Keyan Miao, Yilan You, Jingyang Li, Jianfeng Lu, Yan Zhang
Format:	Article
Language:	English
Published:	BMC 2023-11-01
Subjects:	Intrahepatic cholestasis of pregnancy Urine metabolite Diagnostic biomarker 3-hydroxypropionic acid Uracil
Online Access:	https://doi.org/10.1186/s12884-023-06102-6