Altered GABAergic signaling and chloride homeostasis in eye movement circuits during late neurodevelopment: implications for Alzheimer’s disease therapy

Eye movement deficits, including abnormal saccades and impaired smooth pursuits, are among the earliest observable indicators of neurodegenerative diseases, particularly Alzheimer’s disease (AD). These deficits arise from dysfunctions in neural circuits controlling oculomotor function, including the...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Christophe Porcher, Claudio Rivera, Igor Medina, Lejla Koric
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-10-01
Subjects:	Alzheimer oculomotor KCC2 GABA chloride homeostasis
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1675799/full