Exploring novel ligands for mGluR5: Design, computational analysis, and protein-ligand interaction studies

Abstracts: Metabotropic glutamate receptors (mGluRs) are G-protein-coupled receptors activated by glutamate. A series of 90 novel compounds have been assessed as mGluR5 receptor antagonists. These compounds, selected post-ADMET filtering according to Lipinski's rule of five, represent structura...

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Bibliographic Details

Published in:	Chemical Physics Impact
Main Authors:	Chandraprakash Gond, Nikhil Kumar, Vijay Kumar Singh, Anupama Datta, Anjani Kumar Tiwari
Format:	Article
Language:	English
Published:	Elsevier 2024-12-01
Subjects:	mGluR5 Docking MD Simulation CADD
Online Access:	http://www.sciencedirect.com/science/article/pii/S2667022424002354