circCRKL, a circRNA derived from CRKL, regulates BCR-ABL via sponging miR-877-5p to promote chronic myeloid leukemia cell proliferation

Abstract Background The BCR-ABL fusion protein is the key factor that results in the occurrence of chronic myeloid leukemia (CML). Imatinib (IM) is a targeted inhibitor of BCR-ABL to achieve complete remission. However, remission failure occurs due to acquired resistance caused by secondary BCR-ABL...

Full description

Bibliographic Details
Published in:Journal of Translational Medicine
Main Authors: Jianming Wang, Yang Liang, Yuefeng Qin, Guoyun Jiang, Yuhang Peng, Wenli Feng
Format: Article
Language:English
Published: BMC 2022-09-01
Subjects:
Chronic myeloid leukemia
circCRKL
Proliferation
BCR-ABL
ceRNA
Online Access:https://doi.org/10.1186/s12967-022-03586-2

Internet

https://doi.org/10.1186/s12967-022-03586-2

Similar Items