Optimization of bile preparation for liquid biopsy in cholangiocarcinoma focusing on circulating tumor DNA and protein stability

Abstract Liquid biopsy using bile offers a promising non-invasive approach for molecular analysis in cholangiocarcinoma (CCA). However, the stability of key biomarkers, such as proteins and circulating DNA (ctDNA), at room temperature has not been fully elucidated. This study investigates the tempor...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Scientific Reports
المؤلفون الرئيسيون: Jin-Yi Han, Keun Soo Ahn, Min Jae Kim, Tae-Seok Kim, Yong Hoon Kim, Kwang Bum Cho, Koo Jeong Kang
التنسيق: مقال
اللغة:الإنجليزية
منشور في: Nature Portfolio 2025-04-01
الموضوعات:
Standard operating procedures (SOPs)
Cholangiocarcinoma (CCA)
Liquid biopsy
Bile
Circulating tumor DNA (ctDNA)
Protein stability
الوصول للمادة أونلاين:https://doi.org/10.1038/s41598-025-96170-9

الانترنت

https://doi.org/10.1038/s41598-025-96170-9

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