The endogenous neuropeptide calcitonin gene-related peptide after spontaneous subarachnoid hemorrhage–A potential psychoactive prognostic serum biomarker of pain-associated neuropsychological symptoms

BackgroundThe pronociceptive neuromediator calcitonin gene-related peptide (CGRP) is associated with pain transmission and modulation. After spontaneous subarachnoid hemorrhage (sSAH), the vasodilatory CGRP is excessively released into cerebrospinal fluid (CSF) and serum and modulates psycho-behavio...

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Bibliographic Details

Published in:	Frontiers in Neurology
Main Authors:	Elisabeth Bründl, Martin Proescholdt, Eva-Maria Störr, Petra Schödel, Sylvia Bele, Florian Zeman, Christoph Hohenberger, Martin Kieninger, Nils Ole Schmidt, Karl-Michael Schebesch
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-07-01
Subjects:	biomarker calcitonin gene-related peptide (CGRP) cognitive impairment health-related quality of life (hrQoL) neuropeptide pain
Online Access:	https://www.frontiersin.org/articles/10.3389/fneur.2022.889213/full