Intellectual disability-causing mutations in KIF11 impair microtubule dynamics and dendritic arborization

Abstract Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disabilities (MCLID) is a rare disease caused by mutations in the mitotic motor KIF11. However, the specific neuronal functions of KIF11, its mechanisms of microtubule (MT) regulation, and the impact of MCLID mutati...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Jenna L. Wingfield, Lukas Niese, Yosef Avchalumov, Xiaodan Liu, Rahul Grover, Yoshihisa Nakahata, Bindu L. Raveendra, Adrian E. Gonzalez-Santiago, Jackson P. Carter, Ryohei Yasuda, Jason X.-J. Yuan, Stefan Diez, Sathyanarayanan V. Puthanveettil
Format:	Article
Language:	English
Published:	Nature Portfolio 2026-03-01
Online Access:	https://doi.org/10.1038/s41467-026-70522-z