RasGRP2 inhibits glyceraldehyde-derived toxic advanced glycation end-products from inducing permeability in vascular endothelial cells

Abstract Advanced glycation end-products (AGEs) are formed by the non-enzymatic reaction of sugars and proteins. Among the AGEs, glyceraldehyde-derived toxic AGEs (TAGE) are associated with various diseases, including diabetic complications such as diabetic retinopathy (DR). The risk of developing D...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Jun-ichi Takino, Takuma Sato, Takumi Kanetaka, Kasumi Okihara, Kentaro Nagamine, Masayoshi Takeuchi, Takamitsu Hori
Format:	Article
Language:	English
Published:	Nature Portfolio 2021-02-01
Online Access:	https://doi.org/10.1038/s41598-021-82619-0