Donanemab exposure and efficacy relationship using modeling in Alzheimer's disease

Abstract INTRODUCTION Donanemab is an amyloid‐targeting therapy that specifically targets brain amyloid plaques. The objective of these analyses was to characterize the relationship of donanemab exposure with plasma biomarkers and clinical efficacy through modeling. METHODS Data for the analyses wer...

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Bibliographic Details

Published in:	Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Main Authors:	Ivelina Gueorguieva, Brian A. Willis, Laiyi Chua, Kay Chow, C. Steven Ernest II, Jian Wang, Sergey Shcherbinin, John R. Sims, Emmanuel Chigutsa
Format:	Article
Language:	English
Published:	Wiley 2023-04-01
Subjects:	Alzheimer's disease amyloid plaques Clinical Dementia Rating‐Sum of Boxes donanemab integrated Alzheimer’s Disease Rating Scale modeling
Online Access:	https://doi.org/10.1002/trc2.12404