Structure and neutralization mechanism of a human antibody targeting a complex Epitope on Zika virus.

We currently have an incomplete understanding of why only a fraction of human antibodies that bind to flaviviruses block infection of cells. Here we define the footprint of a strongly neutralizing human monoclonal antibody (mAb G9E) with Zika virus (ZIKV) by both X-ray crystallography and cryo-elect...

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Bibliographic Details

Published in:	PLoS Pathogens
Main Authors:	Cameron Adams, Derek L Carbaugh, Bo Shu, Thiam-Seng Ng, Izabella N Castillo, Ryan Bhowmik, Bruno Segovia-Chumbez, Ana C Puhl, Stephen Graham, Sean A Diehl, Helen M Lazear, Shee-Mei Lok, Aravinda M de Silva, Lakshmanane Premkumar
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2023-01-01
Online Access:	https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1010814&type=printable