SUV39H1 facilitate the osteogenic differentiation of dental pulp stem cells by modulating lipid metabolism and mitochondrial dynamics through FASN via non-histone methylation and ubiquitination mechanism

Abstract Background Tissue engineering technology has limited application in bone tissue regeneration because the mechanism remains unclear. SUV39H1 is a well-characterized histone methyltransferase, but its specific role in bone regeneration of dental pulp stem cells(DPSCs) remains unclear. Mitocho...

Full description

Bibliographic Details

Published in:	Stem Cell Research & Therapy
Main Authors:	Ning Wang, Wanqing Wang, Xiao Han, Yangyang Cao, Haoqing Yang, Chen Zhang, Huina Liu, Mengyuan Zhu, Dengsheng Xia, Zhipeng Fan
Format:	Article
Language:	English
Published:	BMC 2025-09-01
Subjects:	SUV39H1 Dental pulp stem cells (DPSCs) Osteogenic differentiation FASN miR-4788
Online Access:	https://doi.org/10.1186/s13287-025-04657-z