Modular synthesis of clickable peptides via late-stage maleimidation on C(7)-H tryptophan

Abstract Cyclic peptides have attracted tremendous attention in the pharmaceutical industry owing to their excellent cell penetrability, stability, thermostability, and drug-like properties. However, the currently available facile methodologies for creating such peptides are rather limited. Herein,...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Peng Wang, Jiang Liu, Xiaomei Zhu, Kenry, Zhengqing Yan, Jiahui Yan, Jitong Jiang, Manlin Fu, Jingyan Ge, Qing Zhu, Yuguo Zheng
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-07-01
Online Access:	https://doi.org/10.1038/s41467-023-39703-y