Beyond the Complement Cascade: Insights into Systemic Immunosenescence and Inflammaging in Age-Related Macular Degeneration and Current Barriers to Treatment

Landmark genetic studies have revealed the effect of complement biology and its regulation on the pathogenesis of age-related macular degeneration (AMD). Limited phase 3 clinical trial data showing a benefit of complement inhibition in AMD raises the prospect of more complex mediators at play. Subst...

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Bibliographic Details

Published in:	Cells
Main Authors:	Adnan H. Khan, Itay Chowers, Andrew J. Lotery
Format:	Article
Language:	English
Published:	MDPI AG 2023-06-01
Subjects:	immunosenescence inflammaging age-related macular degeneration macular degeneration senolytics
Online Access:	https://www.mdpi.com/2073-4409/12/13/1708