Housecleaning of pyrimidine nucleotide pool coordinates metabolic adaptation of nongrowing Mycobacterium tuberculosis

The ability of Mycobacterium tuberculosis (Mtb) to adopt a slowly growing or nongrowing state within the host plays a critical role for the bacilli to persist in the face of a prolonged multidrug therapy, establish latency and sustain chronic infection. In our previous study, we revealed that genome...

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Bibliographic Details

Published in:	Emerging Microbes and Infections
Main Authors:	Kun-Xiong Shi, Yong-Kai Wu, Bi-Kui Tang, Guo-Ping Zhao, Liang-Dong Lyu
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2019-01-01
Subjects:	Mycobacterium tuberculosis dormancy nongrowing state pyrimidine metabolism mazG
Online Access:	https://www.tandfonline.com/doi/10.1080/22221751.2018.1559706