Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells

CD4+ T cells differentiate into T helper cell subsets in feedforward manners with synergistic signals from the T cell receptor (TCR), cytokines, and lineage-specific transcription factors. Naive CD4+ T cells avoid spontaneous engagement of feedforward mechanisms but retain a prepared state. T cells...

全面介绍

书目详细资料

发表在:	Cell Reports
Main Authors:	Darienne R. Myers, Tannia Lau, Evan Markegard, Hyung W. Lim, Herbert Kasler, Minghua Zhu, Andrea Barczak, John P. Huizar, Julie Zikherman, David J. Erle, Weiguo Zhang, Eric Verdin, Jeroen P. Roose
格式:	文件
语言:	英语
出版:	Elsevier 2017-05-01
主题:	tonic signals T cells LAT HDAC gene expression Th2 Nur77 Irf4
在线阅读:	http://www.sciencedirect.com/science/article/pii/S2211124717306058