Oncogenic role of fumarate hydratase in breast cancer: metabolic reprogramming and mechanistic insights

Abstract Breast cancer remains the most prevalent malignancy among women globally, with its complexity linked to genetic variations and metabolic alterations within tumor cells. This study investigates the role of fumarate hydratase (FH), a key enzyme in the tricarboxylic acid (TCA) cycle, in breast...

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Bibliographic Details

Published in:	Cancer & Metabolism
Main Authors:	Shyng-Shiou F. Yuan, Anupama Vadhan, Hieu D. H. Nguyen, Pang-Yu Chen, Chih-Huang Tseng, Ching-Hu Wu, Yu-Chieh Chen, Yi-Chia Wu, Stephen Chu‐Sung Hu, Steven Lo, Ming-Feng Hou, Yen-Yun Wang
Format:	Article
Language:	English
Published:	BMC 2025-05-01
Online Access:	https://doi.org/10.1186/s40170-025-00397-z