Genomic Analysis of Influenza A and B Viruses Carrying Baloxavir Resistance-Associated Substitutions Serially Passaged in Human Epithelial Cells

Baloxavir marboxil (baloxavir) is an FDA-approved inhibitor of the influenza virus polymerase acidic (PA) protein. Here, we used next-generation sequencing to compare the genomic mutational profiles of IAV H1N1 and H3N2, and IBV wild type (WT) and mutants (MUT) viruses carrying baloxavir resistance-...

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書誌詳細

出版年:	Viruses
主要な著者:	Brady T. Hickerson, Bruce K. Huang, Svetlana N. Petrovskaya, Natalia A. Ilyushina
フォーマット:	論文
言語:	英語
出版事項:	MDPI AG 2023-12-01
主題:	influenza baloxavir resistance polymerase substitutions viral mutation
オンライン･アクセス:	https://www.mdpi.com/1999-4915/15/12/2446