Modulation of the pre-metastatic bone niche: molecular changes mediated by bone-homing prostate cancer extracellular vesicles

Prostate cancer (PCa) is a leading male malignancy worldwide, often progressing to bone metastasis, with limited curative options. Extracellular vesicles (EVs) have emerged as key players in cancer communication and metastasis, promoting the formation of supportive microenvironments in distant sites...

Full description

Bibliographic Details

Published in:	Frontiers in Cell and Developmental Biology
Main Authors:	Thomas J. Brown, Catrin S. Rutland, Katie K. Choi, Feng Tse, Mandy J. Peffers, Nigel P. Mongan, Kenton P. Arkill, Alison Ritchie, Philip A. Clarke, Hari Ratan, Cinzia Allegrucci, Anna M. Grabowska, Victoria James
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-02-01
Subjects:	extracellular vesicles prostate cancer bone metastasis pre-metastatic niche osteocytes
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2024.1354606/full