Metformin reveals a mitochondrial copper addiction of mesenchymal cancer cells.

The clinically approved drug metformin has been shown to selectively kill persister cancer cells through mechanisms that are not fully understood. To provide further mechanistic insights, we developed a drug surrogate that phenocopies metformin and can be labeled in situ by means of click chemistry....

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Sebastian Müller, Antoine Versini, Fabien Sindikubwabo, Guillaume Belthier, Supaporn Niyomchon, Julie Pannequin, Laurence Grimaud, Tatiana Cañeque, Raphaël Rodriguez
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2018-01-01
Online Access:	http://europepmc.org/articles/PMC6219783?pdf=render