The inhibitory effect of adenosine on tumor adaptive immunity and intervention strategies

Adenosine (Ado) is significantly elevated in the tumor microenvironment (TME) compared to normal tissues. It binds to adenosine receptors (AdoRs), suppressing tumor antigen presentation and immune cell activation, thereby inhibiting tumor adaptive immunity. Ado downregulates major histocompatibility...

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Bibliographic Details

Published in:	Acta Pharmaceutica Sinica B
Main Authors:	Longsheng Wang, Jie Zhang, Wenxin Zhang, Mingming Zheng, Hongjie Guo, Xiaohui Pan, Wen Li, Bo Yang, Ling Ding
Format:	Article
Language:	English
Published:	Elsevier 2024-05-01
Subjects:	Adenosine Adenosine receptors Adenosine-generating enzymes Tumor microenvironment Immune suppression Immune escape
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211383523004720