Nuclear translocation of SIRT4 mediates deacetylation of U2AF2 to modulate renal fibrosis through alternative splicing-mediated upregulation of CCN2

TGF-β stimulates CCN2 expression which in turn amplifies TGF-β signaling. This process promotes extracellular matrix production and accelerates the pathological progression of fibrotic diseases. Alternative splicing plays an important role in multiple disease development, while U2 small nuclear RNA...

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Bibliographic Details

Published in:	eLife
Main Authors:	Guangyan Yang, Jiaqing Xiang, Xiaoxiao Yang, Xiaomai Liu, Yanchun Li, Lixing Li, Lin Kang, Zhen Liang, Shu Yang
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2024-11-01
Subjects:	kidney fibrosis pre-mRNA splicing U2 snRNP SIRT4 U2AF2 CCN2
Online Access:	https://elifesciences.org/articles/98524