Impact of mitochondrial metabolism on T-cell dysfunction in chronic lymphocytic leukemia

T cells play a central role in anti-tumor immunity, yet their function is often compromised within the immunosuppressive tumor microenvironment, leading to cancer progression and resistance to immunotherapies. T-cell activation and differentiation require dynamic metabolic shifts, with mitochondrial...

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Bibliographic Details

Published in:	Frontiers in Cell and Developmental Biology
Main Authors:	Wael Gamal, Melanie Mediavilla-Varela, Vishaal Kunta, Eva Sahakian, Javier Pinilla-Ibarz
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-04-01
Subjects:	CLL (chronic lymphocytic leukemia) T-cell exhaustion mitochondria CAR T cell cancer adoptive cell immunotherapy
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2025.1577081/full