O-GlcNAcylation regulates extracellular signal-regulated kinase (ERK) activation in Alzheimer’s disease

IntroductionAberrant activation of Extracellular Signal-Regulated Kinase (ERK) signaling is associated with Alzheimer’s disease (AD) pathogenesis. For example, enhanced ERK signal activation mediated by Apolipoprotein E4 (APOE4), which is a critical genetic risk factor for AD, increases the transcri...

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الحاوية / القاعدة:	Frontiers in Aging Neuroscience
المؤلفون الرئيسيون:	Sophiya John Ephrame, Gentry K. Cork, Victoria Marshall, Margaret A. Johnston, Jenna Shawa, Ibtihal Alghusen, Amy Qiang, Aspin R. Denson, Marisa S. Carman, Halyna Fedosyuk, Russell H. Swerdlow, Chad Slawson
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Frontiers Media S.A. 2023-07-01
الموضوعات:	O-GlcNAc OGT OGA ERK APP Alzheimer’s disease
الوصول للمادة أونلاين:	https://www.frontiersin.org/articles/10.3389/fnagi.2023.1155630/full