Tumor Microenvironment-Responsive Polymeric iRGD and Doxorubicin Conjugates Reduce Spontaneous Lung Metastasis in an Orthotopic Breast Cancer Model

Tremendous progress has been made in the field of nanomedicine for cancer treatment. However, most of the research to date has been focused on inhibiting primary tumor growth with comparatively less efforts directed towards managing tumor metastasis. Here, we introduce a polymeric conjugate P-DOX-iR...

Full description

Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Zheng-Hong Peng, Chinmay M. Jogdeo, Jing Li, Ying Xie, Yazhe Wang, Yuri M. Sheinin, Jindřich Kopeček, David Oupický
Format:	Article
Language:	English
Published:	MDPI AG 2022-08-01
Subjects:	breast cancer cancer metastasis iRGD doxorubicin splenomegaly hematopoiesis
Online Access:	https://www.mdpi.com/1999-4923/14/8/1725