Cathepsin D is essential for the degradomic shift of macrophages required to resolve liver fibrosis

Background and objectives: Fibrosis contributes to 45% of deaths in industrialized nations and is characterized by an abnormal accumulation of extracellular matrix (ECM). There are no specific anti-fibrotic treatments for liver fibrosis, and previous unsuccessful attempts at drug development have fo...

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Bibliographic Details

Published in:	Molecular Metabolism
Main Authors:	Paloma Ruiz-Blázquez, María Fernández-Fernández, Valeria Pistorio, Celia Martinez-Sanchez, Michele Costanzo, Paula Iruzubieta, Ekaterina Zhuravleva, Júlia Cacho-Pujol, Silvia Ariño, Alejandro Del Castillo-Cruz, Susana Núñez, Jesper B. Andersen, Margherita Ruoppolo, Javier Crespo, Carmen García-Ruiz, Luigi Michele Pavone, Thomas Reinheckel, Pau Sancho-Bru, Mar Coll, José C. Fernández-Checa, Anna Moles
Format:	Article
Language:	English
Published:	Elsevier 2024-09-01
Subjects:	Fibrosis Protease Cathepsin Resolution Macrophage
Online Access:	http://www.sciencedirect.com/science/article/pii/S2212877824001200