Imbalanced globin chain synthesis determines erythroid cell pathology in thalassemic mice

Background β-thalassemia occurs from the imbalanced globin chain synthesis due to the absence or inadequate β-globin chain production. The excessive unbound α-globin chains precipitate in erythroid precursors and mature red blood cells leading to ineffective erythropoiesis and hemolysis.Design and M...

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Bibliographic Details

Published in:	Haematologica
Main Authors:	Kanitta Srinoun, Saovaros Svasti, Worrakavee Chumworathayee, Jim Vadolas, Phantip Vattanaviboon, Suthat Fucharoen, Pranee Winichagoon
Format:	Article
Language:	English
Published:	Ferrata Storti Foundation 2009-09-01
Online Access:	https://haematologica.org/article/view/5342