The attenuation of insulin-like growth factor signaling may be responsible for relative reduction in matrix synthesis in degenerated areas of osteoarthritic cartilage

Abstract Background In osteoarthritis (OA), cartilage matrix is lost gradually despite enhanced matrix synthesis by chondrocytes. This paradox may be explained, at least partly, by reduced chondrocyte anabolism in degenerated area of OA cartilage. However, to date, it is not known why chondrocyte an...

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Bibliographic Details

Published in:	BMC Musculoskeletal Disorders
Main Authors:	Nobuho Tanaka, Hirotaka Tsuno, Satoru Ohashi, Mitsuyasu Iwasawa, Hiroshi Furukawa, Tomohiro Kato, Naoshi Fukui
Format:	Article
Language:	English
Published:	BMC 2021-02-01
Subjects:	Osteoarthritis Chondrocyte Matrix synthesis Laser capture microdissection IGF IGF1R
Online Access:	https://doi.org/10.1186/s12891-021-04096-w