Synthetic Analogues of Aminoadamantane as Influenza Viral Inhibitors—In Vitro, In Silico and QSAR Studies

A series of nineteen amino acid analogues of amantadine (Amt) and rimantadine (Rim) were synthesized and their antiviral activity was evaluated against influenza virus A (H3N2). Among these analogues, the conjugation of rimantadine with glycine illustrated high antiviral activity combined with low c...

Full description

Bibliographic Details

Published in:	Molecules
Main Authors:	Radoslav Chayrov, Nikolaos A. Parisis, Maria V. Chatziathanasiadou, Eleni Vrontaki, Kalliopi Moschovou, Georgia Melagraki, Hristina Sbirkova-Dimitrova, Boris Shivachev, Michaela Schmidtke, Yavor Mitrev, Martin Sticha, Thomas Mavromoustakos, Andreas G. Tzakos, Ivanka Stankova
Format:	Article
Language:	English
Published:	MDPI AG 2020-09-01
Subjects:	adamantane derivatives amino acids 3D-QSAR molecular docking X-Ray crystallography plasma stability
Online Access:	https://www.mdpi.com/1420-3049/25/17/3989