Timing matters in macrophage/CD4+ T cell interactions: an agent-based model comparing Mycobacterium tuberculosis host-pathogen interactions between latently infected and naïve individuals

ABSTRACT Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a significant health challenge. Clinical manifestations of TB exist across a spectrum with a majority of infected individuals remaining asymptomatic, commonly referred to as latent TB infection (LTBI). In vitro models ha...

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Bibliographic Details

Published in:	mSystems
Main Authors:	Alexis Hoerter, Alexa Petrucciani, Jordan Bonifacio, Eusondia Arnett, Larry S. Schlesinger, Elsje Pienaar
Format:	Article
Language:	English
Published:	American Society for Microbiology 2025-03-01
Subjects:	tuberculosis agent based model trained immunity granuloma formation host-cell interactions host response
Online Access:	https://journals.asm.org/doi/10.1128/msystems.01290-24