Poly(ADP-ribosyl)ation of acetyltransferase NAT10 by PARP1 is required for its nucleoplasmic translocation and function in response to DNA damage

Abstract Background N-acetyltransferase 10 (NAT10), an abundant nucleolar protein with both lysine and RNA cytidine acetyltransferase activities, has been implicated in Hutchinson-Gilford progeria syndrome and human cancer. We and others recently demonstrated that NAT10 is translocated from the nucl...

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Bibliographic Details

Published in:	Cell Communication and Signaling
Main Authors:	Hong-Yi Liu, Ying-Ying Liu, Yin-Ling Zhang, Yan Ning, Fang-Lin Zhang, Da-Qiang Li
Format:	Article
Language:	English
Published:	BMC 2022-08-01
Subjects:	DNA damage response Nucleoplasmic translocation Nucleolar localization signal Posttranslational modification PARylation
Online Access:	https://doi.org/10.1186/s12964-022-00932-1