Oxidative and Endoplasmic Reticulum Stress Represent Novel Therapeutic Targets for Choroideremia

Choroideremia (CHM) is a rare X-linked chorioretinal dystrophy, affecting the photoreceptors, retinal pigment epithelium (RPE) and choroid, with no approved therapy. CHM is caused by mutations in the <i>CHM</i> gene, which encodes the ubiquitously expressed Rab escort protein 1 (REP1). R...

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Bibliographic Details

Published in:	Antioxidants
Main Authors:	Hajrah Sarkar, Manuela Lahne, Neelima Nair, Mariya Moosajee
Format:	Article
Language:	English
Published:	MDPI AG 2023-08-01
Subjects:	choroideremia oxidative stress ER stress neuroprotectants zebrafish patient fibroblasts
Online Access:	https://www.mdpi.com/2076-3921/12/9/1694