Granulosa cell-derived miR-379-5p regulates macrophage polarization in polycystic ovarian syndrome

Polycystic ovarian syndrome (PCOS) is associated with hyperandrogenemia and ovarian antral follicle growth arrest. We have previously demonstrated that androgen-induced exosomal release of miR-379-5p (miR379) from preantral follicle granulosa cells increases the proliferation of target cells via pho...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Reza Salehi, Meshach Asare-Werehene, Brandon A. Wyse, Atefeh Abedini, Bo Pan, Alex Gutsol, Sahar Jahangiri, Peter Szaraz, Kevin D. Burns, Barbara Vanderhyden, Julang Li, Dylan Burger, Clifford L. Librach, Benjamin K. Tsang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-03-01
Subjects:	miR-379-5p PCOS (polycystic ovarian syndrome) macrophage PDK1 granulosa cells extracellular vesicle
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1104550/full