Osthole induces accumulation of impaired autophagosome against pancreatic cancer cells

Abstract Pancreatic cancer (PC) is one of the most aggressive malignancies worldwide, and few effective therapeutics are available. Osthole (OST), a natural coumarin, has been proven to be a potential anticancer compound. In this study, we found that OST significantly inhibited PC growth both in vit...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Ningna Weng, Sujuan Lv, Hong Chen, Hanchen Zheng, Tong Lin, Qing Zhu, Kai Zhu, Sha Huang
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-12-01
Subjects:	Osthole Pancreatic cancer Autophagy ATF3 mTOR
Online Access:	https://doi.org/10.1038/s41598-024-81911-z