BMP9 reduces age-related bone loss in mice by inhibiting osteoblast senescence through Smad1-Stat1-P21 axis

BMP9 inhibits cellular senescence by activation of Smad1, which suppresses the transcription of Stat1, resulting in decreased P21 expression and SASPs production in osteoblast. The anti-aging effect of BMP9 is benefit to improving age-related osteoporosis.

Bibliographic Details

Published in:	Cell Death Discovery
Main Authors:	Jing-zun Xu, Yan-man Zhou, Lin-lin Zhang, Xiao-jing Chen, Yu-ying Yang, Deng Zhang, Ke-cheng Zhu, Xiao-ke Kong, Li-hao Sun, Bei Tao, Hong-yan Zhao, Jian-min Liu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2022-05-01
Online Access:	https://doi.org/10.1038/s41420-022-01048-8