The Orai1-AC8 Interplay: How Breast Cancer Cells Escape from Orai1 Channel Inactivation

The interplay between the Ca<sup>2+</sup>-sensitive adenylyl cyclase 8 (AC8) and Orai1 channels plays an important role both in the activation of the cAMP/PKA signaling and the modulation of Orai1-dependent Ca<sup>2+</sup> signals. AC8 interacts with a N-terminal region that...

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Bibliographic Details
Published in:Cells
Main Authors: José Sánchez-Collado, José J. López, Juan A. Rosado
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Subjects:
Online Access:https://www.mdpi.com/2073-4409/10/6/1308