Early‐onset Alzheimer's disease explained by polygenic risk of late‐onset disease?

Abstract Early‐onset Alzheimer's disease (AD) is highly heritable, yet only 10% of cases are associated with known pathogenic mutations. For early‐onset AD patients without an identified autosomal dominant cause, we hypothesized that their early‐onset disease reflects further enrichment of the...

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Bibliographic Details
Published in:Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Main Authors: William G. Mantyh, J. Nicholas Cochran, Jared W. Taylor, Iris J. Broce, Ethan G. Geier, Luke W. Bonham, Ashlyn G. Anderson, Daniel W. Sirkis, Renaud La Joie, Leonardo Iaccarino, Kiran Chaudhary, Lauren Edwards, Amelia Strom, Harli Grant, Isabel E. Allen, Zachary A. Miller, Marilu L. Gorno‐Tempini, Joel H. Kramer, Bruce L. Miller, Rahul S. Desikan, Gil D. Rabinovici, Jennifer S. Yokoyama
Format: Article
Language:English
Published: Wiley 2023-10-01
Subjects:
age of onset
biomarkers
early‐onset Alzheimer's disease
late‐onset Alzheimer's disease
polygenic risk
Online Access:https://doi.org/10.1002/dad2.12482

Internet

https://doi.org/10.1002/dad2.12482

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