Reconstructing a B-cell Clonal Lineage. II. Mutation, Selection, and Affinity Maturation

Affinity maturation of the antibody response is a fundamental process in adaptive immunity during which B cells activated by infection or vaccination undergo rapid proliferation accompanied by the acquisition of point mutations in their rearranged immunoglobulin (Ig) genes and selection for increase...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Thomas B. Kepler, Supriya eMunshaw, Ruijun eZhang, Jae-Sung eYu, Christopher W. Woods, Thomas N. Denny, Georgia D. Tomaras, S. Munir Alam, M. Anthony Moody, Garnett eKelsoe, Hua-Xin eLiao, Barton F. Haynes
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2014-04-01
Subjects:	phylogenetics somatic hypermutation Antibody affinity maturation Experimental Influenza Infection Antibody Selection
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00170/full