Time-course transcriptomics reveals the impact of Treponema pallidum on microvascular endothelial cell function and phenotype

Syphilis, caused by Treponema pallidum subsp. pallidum, is an urgent global public health threat. Syphilis vaccine development has been impeded by limited understanding of the molecular mechanisms that enable T. pallidum to establish and maintain infection. The vascular endothelium is critical for T...

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Bibliographic Details

Published in:	Frontiers in Microbiology
Main Authors:	Sean Waugh, Mara C. Goodyear, Alloysius Gomez, Akash Ranasinghe, Karen V. Lithgow, Reza Falsafi, Robert E. W. Hancock, Amy H. Lee, Caroline E. Cameron
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-10-01
Subjects:	syphilis vaccine transcriptomics Treponema pallidum endothelial cell pathogenesis
Online Access:	https://www.frontiersin.org/articles/10.3389/fmicb.2025.1649738/full