Antigenic “Hot- Spots” on the TSH Receptor Hinge Region

The TSH receptor (TSHR) hinge region was previously considered an inert scaffold connecting the leucine-rich ectodomain to the transmembrane region of the receptor. However, mutation studies have established the hinge region to be an extended hormone-binding site in addition to containing a region w...

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Bibliographic Details

Published in:	Frontiers in Endocrinology
Main Authors:	Simeng Sun, Sarawut Summachiwakij, Ora Schneck, Syed A. Morshed, Risheng Ma, Rauf Latif, Terry F. Davies
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-01-01
Subjects:	TSH receptor hinge antibodies neutral antibodies ectdomain Graves' disease (GD)
Online Access:	https://www.frontiersin.org/article/10.3389/fendo.2018.00765/full