Alternative polyadenylation reprogramming of MORC2 induced by NUDT21 loss promotes KIRC carcinogenesis

Alternative polyadenylation (APA), a posttranscriptional mechanism of gene expression via determination of 3′UTR length, has an emerging role in carcinogenesis. Although abundant APA reprogramming is found in kidney renal clear cell carcinoma (KIRC), which is one of the major malignancies, whether A...

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Bibliographic Details

Published in:	JCI Insight
Main Authors:	Yuqin Tan, Tong Zheng, Zijun Su, Min Chen, Suxiang Chen, Rui Zhang, Ruojiao Wang, Ke Li, Ning Na
Format:	Article
Language:	English
Published:	American Society for Clinical investigation 2023-09-01
Subjects:	Oncology
Online Access:	https://doi.org/10.1172/jci.insight.162893