Action of CMG with strand-specific DNA blocks supports an internal unwinding mode for the eukaryotic replicative helicase
Replicative helicases are ring-shaped hexamers that encircle DNA for duplex unwinding. The currently accepted view of hexameric helicase function is by steric exclusion, where the helicase encircles one DNA strand and excludes the other, acting as a wedge with an external DNA unwinding point during...
| Published in: | eLife |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2017-03-01
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| Subjects: | |
| Online Access: | https://elifesciences.org/articles/23449 |