Association Between Local Skin Reactions and Efficacy with 5-Fluorouracil 4% Cream in Actinic Keratosis: A Post-Hoc Analysis of Two Randomised Clinical Trials

Abstract Introduction Topical 5-fluorouracil (5-FU), 5% or 4% cream, is recommended among first-line treatments for actinic keratosis (AK). Local skin reactions (LSRs) are an expected and transient response to treatment with 5-FU but can lead to treatment discontinuation when severe. This analysis a...

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Bibliographic Details

Published in:	Dermatology and Therapy
Main Authors:	Markus V. Heppt, Kilian Trin, Anne-Cécile Mille, Mélanie Groc, Alain Delarue, Nathalie Bégeault
Format:	Article
Language:	English
Published:	Adis, Springer Healthcare 2025-01-01
Subjects:	5-Fluororuacil 4% Actinic keratosis Erythema Local skin reactions Post hoc analysis
Online Access:	https://doi.org/10.1007/s13555-024-01336-4